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ZIDOVUDINE
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DeCS
Descriptor
English
:
Zidovudine
Descriptor
Spanish
:
Zidovudina
Descriptor
Portuguese
:
Zidovudina
Synonyms
English
:
Azidothymidine
AZT (Antiviral)
Tree Number:
D03.383.742.680.705.950
D13.570.230.500.950
D13.570.230.855.950
D13.570.685.705.950
Definition
English
:
A dideoxynucleoside compound in which the 3'-hydroxy group on the
sugar
moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of
HIV
replication, acting as a chain-terminator of viral
DNA
during
reverse transcription
. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of
bone marrow
, resulting in
anemia
and
leukopenia.
Pharmacological Action:
Anti-HIV Agents
Antimetabolites
Reverse Transcriptase Inhibitors
History Note
English
:
89
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
23867
Unique Identifier:
D015215
Occurrence in VHL
:
Similar:
DeCS
CID-10
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