Search on:
NEUROFILAMENT PROTEINS
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Neurofilament Proteins
Descriptor
Spanish
:
Proteínas de Neurofilamentos
Descriptor
Portuguese
:
Proteínas de Neurofilamentos
Tree Number:
D05.750.078.593.630
D12.776.220.475.630
D12.776.641.630
Definition
English
:
Type III
intermediate filament proteins
that assemble into neurofilaments, the major cytoskeletal element in nerve
axons
and
dendrites
. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV
intermediate filament proteins
form other cytoskeletal
elements
such as
keratins
and
lamins
. It appears that the
metabolism
of neurofilaments is disturbed in Alzheimer's
disease
, as indicated by the presence of neurofilament
epitopes
in the
neurofibrillary tangles
, as well as by the severe reduction of the expression of the gene for the
light
neurofilament subunit of the neurofilament triplet in brains of Alzheimer's
patients
. (Can J Neurol Sci 1990 Aug;17(3):302)
Indexing Annotation
English
:
/biosyn /physiol permitted
History Note
English
:
92; was NEUROFILAMENT PROTEINS (NM) 1977-91
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
29931
Unique Identifier:
D016900
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS