Expresión de búsqueda:
APOPTOSIS INDUCING FACTOR
Descriptores Encontrados:
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DeCS
Descriptor
Inglés
:
Apoptosis Inducing Factor
Descriptor
Español
:
Factor Inductor de la Apoptosis
Descriptor
Portugués
:
Fator de Indução de Apoptose
Categoría:
D08.811.682.608.047
D12.644.360.075.311
D12.776.331.161
D12.776.476.075.311
Definición
Inglés
:
A flavoprotein that functions as a powerful antioxidant in the
MITOCHONDRIA
and promotes
APOPTOSIS
when released from the
mitochondria
. In mammalian
cells
AIF is released in response to pro-apoptotic protein members of the bcl-2 protein
family
. It translocates to the
CELL NUCLEUS
and binds
DNA
to stimulate CASPASE-independent
CHROMATIN
condensation.
Nota de Indización
Inglés
:
INHIBITOR OF APOPTOSIS PROTEINS
is also available
Nota Histórica
Inglés
:
2006(1999)
Calificadores Permitidos
Inglés
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número del Registro:
50601
Identificador Único:
D051033
Ocurrencia en la BVS
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS