Search on: SLOW REACTING SUBSTANCE OF ANAPHYLAXIS 
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Descriptor English:   SRS-A 
Descriptor Spanish:   SRS-A 
Descriptor Portuguese:   SRS-A 
Synonyms English:   Slow Reacting Substance of Anaphylaxis  
Tree Number:   D10.251.355.255.100.450.855
D23.469.050.175.450.725
Definition English:   A group of LEUKOTRIENES; (LTC4; LTD4; and LTE4) that is the major mediator of BRONCHOCONSTRICTION; HYPERSENSITIVITY; and other allergic reactions. Earlier studies described a "slow-reacting substance of ANAPHYLAXIS" released from lung by cobra venom or after anaphylactic shock. The relationship between SRS-A leukotrienes was established by UV which showed the presence of the conjugated triene. (From Merck Index, 11th ed) 
Indexing Annotation English:   /biosyn /physiol permitted
History Note English:   73(67) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   24317 
Unique Identifier:   D013189 

Occurrence in VHL:
 

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