Search on: SCRAPIE AMYLOID PRECURSOR PROTEIN 
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Descriptor English:   PrPC Proteins 
Descriptor Spanish:   Proteínas PrPC 
Descriptor Portuguese:   Proteínas PrPC 
Synonyms English:   Scrapie Amyloid Precursor Protein  
Tree Number:   D12.776.785.680
Definition English:   Normal cellular isoform of prion proteins (PRIONS) encoded by a chromosomal gene and found in normal and scrapie-infected brain tissue, and other normal tissue. PrPC are protease-sensitive proteins whose function is unknown. Posttranslational modification of PrPC into PrPSC leads to infectivity. 
Indexing Annotation English:   PrPC stands for PRion Protein Cellular; do not confuse with PRPSC PROTEINS which are scrapie prions; /pathogen permitted; DF: PRPC
History Note English:   95; SCRAPIE AMYLOID PRECURSOR PROTEIN was NM 1989-94 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PY pathogenicity
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   32060 
Unique Identifier:   D018621 

Occurrence in VHL:
 

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