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RECEPTORS, POLYMERIC IMMUNOGLOBULIN
Descriptors Found:
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DeCS
Descriptor
English
:
Receptors, Polymeric Immunoglobulin
Descriptor
Spanish
:
Receptores de Inmunoglobulina Polimérica
Descriptor
Portuguese
:
Receptores de Imunoglobulina Polimérica
Synonyms
English
:
Polymeric Immunoglobulin Receptors
Tree Number:
D12.776.543.750.705.871.700
Definition
English
:
Specialized Fc receptors (RECEPTORS, FC) for polymeric
immunoglobulins
, which mediate transcytosis of polymeric
IMMUNOGLOBULIN A
and
IMMUNOGLOBULIN M
into external secretions. They are found on the surfaces of
epithelial cells
and
hepatocytes
. After binding to
IMMUNOGLOBULIN A
, the receptor-ligand complex undergoes
endocytosis
, transport by vesicle, and secretion into the lumen by
exocytosis
. Before release, the part of the receptor (
SECRETORY COMPONENT
) that is bound to
IMMUNOGLOBULIN A
is proteolytically cleaved from its transmembrane
tail
. (From Rosen et al., The
Dictionary
of Immunology, 1989)
Indexing Annotation
English
:
specialized Fc receptors; DF: RECEPT POLY IG
History Note
English
:
96
Allowable Qualifiers
English
:
AD
administration & dosage
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PH
physiology
RE
radiation effects
TU
therapeutic use
UL
ultrastructure
Record Number:
32632
Unique Identifier:
D019056
Occurrence in VHL
:
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