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PROTO-ONCOGENE PROTEIN ERBB-3
Descriptors Found:
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DeCS
Descriptor
English
:
Receptor, erbB-3
Descriptor
Spanish
:
Receptor erbB-3
Descriptor
Portuguese
:
Receptor erbB-3
Synonyms
English
:
c-erbB-3 Protein
erbB-3 Protein
HER-3 Proto-Oncogene Protein
Proto-Oncogene Protein erbB-3
Tree Number:
D08.811.913.696.620.682.725.400.175
D12.776.543.750.060.437
D12.776.543.750.750.400.360
D12.776.624.664.700.790
D23.101.840.721
Definition
English
:
A cell surface protein-tyrosine kinase receptor that is specific for
NEUREGULINS
. It has extensive homology to and can heterodimerize with the EGF Receptor (RECEPTOR,
EPIDERMAL GROWTH FACTOR
) and the erbB-2 receptor (RECEPTOR, ERBB-2). Overexpression of the erbB-3 receptor is associated with tumorigenesis.
History Note
English
:
2000; use RECEPTOR, ERBB-3 (NM) 1990-1999
Allowable Qualifiers
English
:
AD
administration & dosage
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PH
physiology
RE
radiation effects
TU
therapeutic use
UL
ultrastructure
Record Number:
34452
Unique Identifier:
D020893
Occurrence in VHL
:
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CID-10
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