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PROTEIN KINASE C-ALPHA
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DeCS
Descriptor
English
:
Protein Kinase C-alpha
Descriptor
Spanish
:
Proteína Quinasa C-alfa
Descriptor
Portuguese
:
Proteína Quinase C-alfa
Synonyms
English
:
PKC-alpha Serine-Threonine Kinase
Tree Number:
D08.811.913.696.620.682.700.725.100
Definition
English
:
A cytoplasmic
serine
threonine
kinase involved in regulating
CELL DIFFERENTIATION
and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote
PHOSPHORYLATION
of BCL-2
PROTO-ONCOGENE PROTEINS
and chemoresistance in human acute
leukemia
cells.
History Note
English
:
2006(1999)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50721
Unique Identifier:
D051571
Occurrence in VHL
:
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CID-10
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