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PRE-B CELL RECEPTORS
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DeCS
Descriptor
English
:
Pre-B Cell Receptors
Descriptor
Spanish
:
Receptores de Células Precursoras de Linfócitos B
Descriptor
Portuguese
:
Receptores de Células Precursoras de Linfócitos B
Tree Number:
D12.776.124.486.485.950.750
D12.776.124.790.651.950.750
D12.776.377.715.548.950.750
D12.776.543.750.705.816.821.750
Definition
English
:
Membrane proteins
in precursor
B-LYMPHOCYTES
(pre-B
Cells
). They are composed of membrane-bound MU
IMMUNOGLOBULIN HEAVY CHAINS
in complex with SURROGATE
LIGHT
CHAINS instead of conventional
IMMUNOGLOBULIN LIGHT CHAINS
. Only successful rearrangement of the VDJ segments, at the Ig heavy chain gene locus (IMMUNOGLOBULIN HEAVY CHAIN
GENES
), will generate mu heavy chains that can pair with surrogate
light
chains. Thus formation of the
pre-B cell receptors
is an important checkpoint in the development of mature B
cells.
History Note
English
:
2008
Allowable Qualifiers
English
:
AD
administration & dosage
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PH
physiology
RE
radiation effects
TU
therapeutic use
UL
ultrastructure
Record Number:
52788
Unique Identifier:
D054420
Occurrence in VHL
:
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CID-10
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