Search on: MUSCARINIC ANTAGONISTS 
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Descriptor English:   Muscarinic Antagonists 
Descriptor Spanish:   Antagonistas Muscarínicos 
Descriptor Portuguese:   Antagonistas Muscarínicos 
Synonyms English:   Antimuscarinic Agents  
Tree Number:   D27.505.519.625.120.200.500
D27.505.696.577.120.200.500
Definition English:   Drugs that bind to but do not activate muscarinic cholinergic receptors (RECEPTORS, MUSCARINIC), thereby blocking the actions of endogenous acetylcholine or exogenous agonists. Muscarinic antagonists have widespread effects including actions on the iris and ciliary muscle of the eye, the heart and blood vessels, secretions of the respiratory tract, GI system, and salivary glands, GI motility, urinary bladder tone, and the central nervous system. Antagonists that discriminate among the various muscarinic receptor subtypes and might allow better control of peripheral and central actions are under development. 
Indexing Annotation English:   GEN or unspecified; prefer specifics; DF: MUSCARINIC ANTAG
See Related English:   Parasympatholytics
 
History Note English:   95; ANTIMUSCARINIC AGENTS was see PARASYMPATHOLYTICS 1969-94 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DU diagnostic use
EC economics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   32129 
Unique Identifier:   D018727 

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