Search on: MULTIDRUG RESISTANCE PROTEINS 
Descriptors Found: 1
Displaying: 1 .. 1  

 1 / 1 DeCS     
Descriptor English:   P-Glycoproteins 
Descriptor Spanish:   P-Glicoproteínas 
Descriptor Portuguese:   Glicoproteínas P 
Synonyms English:   Multidrug Resistance Proteins  
Tree Number:   D12.776.157.530.100.652
D12.776.157.530.450.074.500.500.875
D12.776.395.550.020.610
D12.776.543.550.192.610
D12.776.543.585.100.610
D12.776.543.585.450.074.500.500.875
Definition English:   A subfamily of transmembrane proteins from the superfamily of ATP-BINDING CASSETTE TRANSPORTERS that are closely related in sequence to P-GLYCOPROTEIN. When overexpressed, they function as ATP-dependent efflux pumps able to extrude lipophilic drugs, especially ANTINEOPLASTIC AGENTS, from cells causing multidrug resistance (DRUG RESISTANCE, MULTIPLE). Although P-Glycoproteins share functional similarities to MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS they are two distinct subclasses of ATP-BINDING CASSETTE TRANSPORTERS, and have little sequence homology. 
Indexing Annotation English:   P-GLYCOPROTEIN is also available; P stands for "permeability"
See Related English:   Drug Resistance, Multiple
Genes, MDR
Multidrug Resistance-Associated Proteins
Rhodamine 123
 
History Note English:   99; use P-GLYCOPROTEIN 1995-98 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   33637 
Unique Identifier:   D018435 

Occurrence in VHL: 		 

Similar:
  
DeCS CID-10 SciELO LILACS LIS