Search on: MEGALIN 
Descriptors Found: 1
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Descriptor English:   LDL-Receptor Related Protein 2 
Descriptor Spanish:   Proteína 2 Relacionada a Receptor LDL 
Descriptor Portuguese:   Proteína 2 Relacionada a Receptor de LDL 
Synonyms English:   Low-Density Lipoprotein Receptor-Related Protein-2
Megalin  
Tree Number:   D12.776.526.200
D12.776.543.750.710.450.500.200
D23.050.422.500.500
Definition English:   An LDL-RECEPTOR RELATED PROTEIN found in the neuroepithelium and in proximal tubular cells of the kidney. It is considered a multiligand receptor in that it binds to a variety of ligands with relatively high affinity and may function in mediating the uptake and lysosomal degradation of macromolecules such as: LIPOPROTEINS; ENDOPEPTIDASES; and PROTEASE INHIBITORS. 
Indexing Annotation English:   not X ref Heymann Nephritis Antigen GP330: HEYMANN NEPHRITIS ANTIGENIC COMPLEX is also available; DF: LRP 2
History Note English:   2002; for HEYMAN'S NEPHRITIS ANTIGEN GP330 use HEYMANN NEPHRITIS ANTIGENIC COMPLEX (NM) 1984-2001; for ANTIGEN GP330, NEPHRITIS use HEYMANN NEPHRITIS ANTIGENIC COMPLEX (NM) 1988-2001; for RENAL GLYCOPROTEIN GP330 use HEYMANN NEPHRITIS ANTIGENIC COMPLEX (NM) 1991-2001; for GP330 ANTIGEN use HEYMANN NEPHRITIS ANTIGENIC COMPLEX (NM) 1991-2001; for LPR-2 use HEYMANN NEPHRITIS ANTIGENIC COMPLEX (NM) 1996-2001; for LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEINS 2 use HEYMANN NEPHRITIS ANTIGENIC COMPLEX (NM) 1994-2001; for MEGALIN use HEYMANN NEPHRITIS ANTIGENIC COMPLEX (NM) 1995-2001 
Allowable Qualifiers English:  
AD administration & dosage AG agonists
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CH chemistry CL classification
DF deficiency DE drug effects
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PH physiology
RE radiation effects TU therapeutic use
UL ultrastructure  
Record Number:   36222 
Unique Identifier:   D026561 

Occurrence in VHL:
 

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