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DeCS
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Descriptor English:
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Histocompatibility Antigens Class I
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Descriptor Spanish:
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Antígenos de Histocompatibilidad Clase I
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Descriptor Portuguese:
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Antígenos de Histocompatibilidade Classe I
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Synonyms English:
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Class I Antigens
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Tree Number:
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D23.050.301.500.400
D23.050.705.552.400
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Definition English:
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Large transmembrane, polymorphic glycoproteins noncovalently associated with nonpolymorphic beta 2-microglobulin. In humans, three structural genes on chromosome 6 code for the HLA-A; HLA-B and HLA-C antigens. In mice, three genes named K, D, and L on chromosome 17 code for the H-2 antigens. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during graft rejection and restrict cell-mediated lysis of virus-infected cells. They are primarily associated with rheumatologic diseases and certain malignant disorders. |
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Indexing Annotation English:
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human & animal
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History Note English:
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89
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Allowable Qualifiers English:
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Record Number:
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23664
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Unique Identifier:
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D015395
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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