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HIRUDIN
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DeCS
Descriptor
English
:
Hirudins
Descriptor
Spanish
:
Hirudinas
Descriptor
Portuguese
:
Hirudinas
Synonyms
English
:
Hirudin
Tree Number:
D12.644.822.750.060.690
D12.644.861.060.690
D12.776.645.750.060.690
D12.776.872.060.690
Definition
English
:
Single-chain polypeptides of about 65
amino acids
(7 kDa) from
LEECHES
that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant
hirudins
lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave
FIBRINOGEN.
Pharmacological Action:
Fibrinolytic Agents
Protease Inhibitors
Entry Combination - descr/qualif
English
:
Hirudins
/
therapeutic use
use
Hirudin Therapy
History Note
English
:
2005(1963)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
29410
Unique Identifier:
D006629
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS