Search on: HEMOGLOBIN, SICKLE 
Descriptors Found: 1
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Descriptor English:   Hemoglobin, Sickle 
Descriptor Spanish:   Hemoglobina Falciforme 
Descriptor Portuguese:   Hemoglobina Falciforme 
Synonyms English:   Hemoglobin S  
Tree Number:   D12.776.124.400.463.588
D12.776.422.316.762.426.588
Definition English:   An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia. 
Indexing Annotation English:   /urine: coord IM with HEMOGLOBINURIA (IM); hemoglobin S disease = ANEMIA, SICKLE CELL; DF: HBS
History Note English:   77(75); was HEMOGLOBIN S 1973-74 (Prov) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   22197 
Unique Identifier:   D006451 

Occurrence in VHL:
 

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