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GPIIB-IIIA RECEPTORS
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DeCS
Descriptor
English
:
Platelet Glycoprotein GPIIb-IIIa Complex
Descriptor
Spanish
:
Complejo GPIIb-IIIa de Glicoproteína Plaquetaria
Descriptor
Portuguese
:
Complexo Glicoproteico GPIIb-IIIa de Plaquetas
Synonyms
English
:
GPIIb-IIIa Receptors
Integrin alphaIIbbeta3
Tree Number:
D12.776.395.550.625.785
D12.776.543.550.625.785
D12.776.543.750.705.408.460.700
D12.776.543.750.705.675.784
Definition
English
:
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and
INTEGRIN BETA3
which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive
proteins
. As such, it is a receptor for
FIBRINOGEN
;
VON WILLEBRAND FACTOR
; FIBRONECTIN;
VITRONECTIN
; and
THROMBOSPONDINS
. A deficiency of GPIIb-IIIa results in GLANZMANN
THROMBASTHENIA.
Entry Combination - descr/qualif
English
:
Platelet Glycoprotein GPIIb-IIIa Complex
/
deficiency
use
Thrombasthenia
See Related
English
:
Thrombasthenia
History Note
English
:
1996(1987); use INTEGRIN ALPHAIIBBETA3 (NM) 1992-1995
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
32647
Unique Identifier:
D019039
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS