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DeCS
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Descriptor English:
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Receptors, GABA-B
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Descriptor Spanish:
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Receptores GABA-B
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Descriptor Portuguese:
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Receptores de GABA-B
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Synonyms English:
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Baclofen Receptors
GABA-B Receptors
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Tree Number:
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D12.776.543.750.100.300
D12.776.543.750.720.200.300.320
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Definition English:
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Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and influence cells via interactions with G-proteins. GABA-B receptors are pharmacologically characterized by their insensitivity to the blocker bicuculline and sensitivity to the agonist L-baclofen. They are found both presynaptically and postsynaptically, and act variously by inhibition of adenylate cyclase, activation of phospholipase A2, activation of potassium channels, and inactivation of voltage-activated calcium channels. |
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Indexing Annotation English:
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DF: RECEPT GABA B
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History Note English:
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94; BACLOFEN RECEPTORS was BACLOFEN RECEPTOR (NM) 1985-93
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Allowable Qualifiers English:
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Record Number:
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31126
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Unique Identifier:
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D018080
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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