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DeCS
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Descriptor English:
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Myelin Basic Proteins
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Descriptor Spanish:
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Proteínas Básicas de Mielina
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Descriptor Portuguese:
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Proteínas Básicas da Mielina
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Synonyms English:
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Encephalitogenic Basic Proteins
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Tree Number:
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D12.776.543.620.540
D12.776.641.580.510
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Definition English:
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A group of 7 proteins produced from a single gene by alternate splicing found in central and peripheral nervous system myelin. The major basic protein (MBP) has long been of interest because it is the antigen, that, when injected into an animal, elicits a cellular immune response that produces the CNS autoimmune disease called experimental allergic encephalomyelitis (ENCEPHALOMYELITIS, ALLERGIC). In the peripheral nervous system, myelin basic protein 18.5-kDa is often referred to as the P1 protein. (From Siegel et al., Basic Neurochemistry, 5th ed, p130, 133) |
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Indexing Annotation English:
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/biosyn /drug eff /physiol /ultrastruct permitted; note X ref: do not index under ENCEPHALOMYELITIS, ALLERGIC unless the disease is discussed; DF: ENCEPH BASIC PROTEINS
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History Note English:
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96; was ENCEPHALITOGENIC BASIC PROTEINS 1973-95 (Prov 1974); MYELIN BASIC PROTEINS was see ENCEPHALITOGENIC BASIC PROTEINS 1979-95
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Allowable Qualifiers English:
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Record Number:
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4756
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Unique Identifier:
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D004676
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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