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DOPAMINERGIC ANTAGONISTS
Descriptors Found:
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DeCS
Descriptor
English
:
Dopamine Antagonists
Descriptor
Spanish
:
Antagonistas de Dopamina
Descriptor
Portuguese
:
Antagonistas de Dopamina
Synonyms
English
:
Dopamine Receptor Antagonists
Dopaminergic Antagonists
Tree Number:
D27.505.519.625.150.175
D27.505.696.577.150.175
Definition
English
:
Drugs that bind to but do not activate
DOPAMINE
RECEPTORS, thereby blocking the actions of
dopamine
or exogenous agonists. Many drugs used in the treatment of
psychotic disorders
(
ANTIPSYCHOTIC AGENTS
) are
dopamine antagonists
, although their therapeutic effects may be due to long-term adjustments of the
brain
rather than to the acute effects of blocking
dopamine
receptors.
Dopamine antagonists
have been used for several other clinical purposes including as
ANTIEMETICS
, in the treatment of
Tourette syndrome
, and for
hiccup
.
Dopamine
receptor blockade is associated with
NEUROLEPTIC MALIGNANT SYNDROME.
Indexing Annotation
English
:
DF:
DOPAMINE
ANTAG
History Note
English
:
95
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
32275
Unique Identifier:
D018492
Occurrence in VHL
:
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CID-10
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