Search on: DIHYDROOROTATE OXIDASE 
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Descriptor English:   Dihydroorotate Oxidase 
Descriptor Spanish:   Dihidroorotato Oxidasa 
Descriptor Portuguese:   Diidrorotato Oxidase 
Tree Number:   D08.811.682.660.300
Definition English:   An enzyme that in the course of pyrimidine biosynthesis, catalyzes the oxidation of dihydro-orotic acid to orotic acid utilizing oxygen as the electron acceptor. This enzyme is a flavoprotein which contains both FLAVIN-ADENINE DINUCLEOTIDE and FLAVIN MONONUCLEOTIDE as well as iron-sulfur centers. EC 1.3.3.1. 
History Note English:   94; was DIHYDRO-OROTATE OXIDASE 1977-93 (see under OXIDOREDUCTASES 1977-90); DIHYDRO-OROTATE DEHYDROGENASE & OROTATE REDUCTASE were see DIHYDRO-OROTATE OXIDASE 1977-93 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   31730 
Unique Identifier:   D004081 

Occurrence in VHL:
 

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