Search on: DNA TOPOISOMERASE II, BACTERIAL 
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Descriptor English:   DNA Topoisomerases, Type II, Bacterial 
Descriptor Spanish:   Topoisomerasas de ADN Tipo II Bacterianas 
Descriptor Portuguese:   DNA Topoisomerases Tipo II Bacterianas 
Synonyms English:   DNA Topoisomerase II, Bacterial  
Tree Number:   D08.811.399.403.741.300
Definition English:   Bacterial enzymes of the DNA TOPOISOMERASES, TYPE II class that catalyze ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. These enzymes bring about relaxation of the supercoiled DNA duplex. Bacterial DNA topoisomerases in the Type II class exist as heterotetramers of 2 subunits, such as 2 gyrA and 2 gyrB in DNA GYRASE. 
History Note English:   2002 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   36088 
Unique Identifier:   D027061 

Occurrence in VHL:
 

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