Search on: DNA TOPOISOMERASE I 
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Descriptor English:   DNA Topoisomerases, Type I 
Descriptor Spanish:   Topoisomerasas de ADN Tipo I 
Descriptor Portuguese:   DNA Topoisomerases Tipo I 
Synonyms English:   DNA Nicking-Closing Protein
DNA Relaxing Enzyme
DNA Relaxing Protein
DNA Topoisomerase I
DNA Untwisting Enzyme
DNA Untwisting Enzymes
DNA Untwisting Protein
DNA Untwisting Proteins
DNA Topoisomerase  
Tree Number:   D08.811.399.403.483
Definition English:   DNA TOPOISOMERASES that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. DNA Topoisomerases, Type I enzymes reduce the topological stress in the DNA structure by relaxing the superhelical turns and knotted rings in the DNA helix. 
Indexing Annotation English:   GEN or unspecified; prefer specifics; do not confuse X ref DNA UNTWISTING PROTEIN with DNA UNWINDING PROTEINS see DNA HELICASES
History Note English:   2002; use DNA TOPOISOMERASE 1994-2001, use DNA UNTWISTING PROTEINS 1978-1993; for DNA NICKING-CLOSING PROTEIN use DNA NICKING-CLOSING PROTEINS 1978-1993; for DNA RELAXING ENZYME use DNA RELAXING ENZYMES 1978-1993; for DNA UNTWISTING ENZYME use DNA UNTWISTING ENZYMES 1978-1993; for OMEGA PROTEIN use OMEGA PROTEINS 1978-1993 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   31732 
Unique Identifier:   D004264 

Occurrence in VHL:
 

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