Search on: DNA TOPOISOMERASE I, BACTERIAL 
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Descriptor English:   DNA Topoisomerases, Type I, Bacterial 
Descriptor Spanish:   Topoisomerases de ADN Tipo I Bacterianas 
Descriptor Portuguese:   DNA Topoisomerases Tipo I Bacterianas 
Synonyms English:   DNA Topoisomerase I, Bacterial  
Tree Number:   D08.811.399.403.483.300
Definition English:   Bacterial enzymes of the DNA TOPOISOMERASES, TYPE I class that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA. 
History Note English:   2002 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   36085 
Unique Identifier:   D027024 

Occurrence in VHL:
 

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