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CLAVULANIC ACID
Descriptors Found:
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DeCS
Descriptor
English
:
Clavulanic Acid
Descriptor
Spanish
:
Ácido Clavulánico
Descriptor
Portuguese
:
Ácido Clavulânico
Synonyms
English
:
Clavulanate
Tree Number:
D02.065.589.099.374.160
D04.075.080.875.099.221.374.160
Definition
English
:
Clavulanic acid
and its
salts
and
esters
. The acid is a
suicide
inhibitor of bacterial beta-lactamase
enzymes
from
Streptomyces
clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with beta-lactam antibiotics prevents antibiotic inactivation by microbial lactamase.
Pharmacological Action:
Anti-Bacterial Agents
Enzyme Inhibitors
Entry Combination - descr/qualif
English
:
Clavulanic Acid
/
analogs & derivatives
use
Clavulanic Acids
History Note
English
:
98; use CLAVULANIC ACID (NM) 1980-97
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
33383
Unique Identifier:
D019818
Occurrence in VHL
:
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