Search on: CITRATE CLEAVAGE ENZYME 
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Descriptor English:   ATP Citrate (pro-S)-Lyase 
Descriptor Spanish:   ATP Citrato (pro-S)-Liasa 
Descriptor Portuguese:   ATP Citrato (pro-S)-Liase 
Synonyms English:   Citrate Cleavage Enzyme
ATP Citrate Lyase
ATP Citrate Synthase  
Tree Number:   D08.811.913.050.331
Definition English:   An enzyme that, in the presence of ATP and COENZYME A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and ORTHOPHOSPHATE. This reaction represents an important step in fatty acid biosynthesis. This enzyme was formerly listed as EC 4.1.3.8. 
History Note English:   98(73) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects SE secretion
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   1282 
Unique Identifier:   D001275 

Occurrence in VHL:
 

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