Search on: BRCA2 PROTEIN 
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Descriptor English:   BRCA2 Protein 
Descriptor Spanish:   Proteína BRCA2 
Descriptor Portuguese:   Proteína BRCA2 
Synonyms English:   Breast Cancer 2 Gene Product
Fanconi Anemia Complementation Group D1 Protein  
Tree Number:   D12.776.313.249
D12.776.624.776.101
D12.776.660.105
Definition English:   A large, nuclear protein, encoded by the BRCA2 gene (GENE, BRCA2). Mutations in this gene predispose humans to breast and ovarian cancer. The BRCA2 protein is an essential component of DNA repair pathways, suppressing the formation of gross chromosomal rearrangements. (from Genes Dev. 2000;14(11):1400-6) 
History Note English:   2002; use BRCA2 PROTEIN (NM) 1995-2001 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   36228 
Unique Identifier:   D024682 

Occurrence in VHL: 		 

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