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DeCS
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Descriptor English:
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Amyloid beta-Protein Precursor
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Descriptor Spanish:
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Precursor de Proteína-beta Amiloide
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Descriptor Portuguese:
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Precursor da beta-Proteína Amilóide
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Synonyms English:
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beta-Amyloid Protein Precursor
Amyloid Protein Precursor
Amyloid A4 Protein Precursor
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Tree Number:
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D12.776.049.025.150
D12.776.811.050
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Definition English:
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A precursor to the AMYLOID BETA-PROTEIN (beta/A4). Alterations in the expression of the amyloid beta-protein precursor (ABPP) gene, located on chromosome 21, plays a role in the development of the neuropathology common to both ALZHEIMER DISEASE and DOWN SYNDROME. ABPP is associated with the extensive extracellular matrix secreted by neuronal cells. Upon cleavage, this precursor produces three proteins of varying amino acid lengths: 695, 751, and 770. The beta/A4 (695 amino acids) or beta-amyloid protein is the principal component of the extracellular amyloid in senile plaques found in ALZHEIMER DISEASE; DOWN SYNDROME and, to a limited extent, in normal aging. |
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Indexing Annotation English:
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/drug eff /ultrastruct permitted; DF: ABPP
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History Note English:
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92; was AMYLOID BETA PROTEIN PRECURSOR (NM) 1988-91; AMYLOID A4 PROTEIN PRECURSOR was NM 1987-94
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Allowable Qualifiers English:
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Record Number:
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30268
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Unique Identifier:
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D016564
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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