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AMILORIDE
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DeCS
Descriptor
English
:
Amiloride
Descriptor
Spanish
:
Amilorida
Descriptor
Portuguese
:
Amilorida
Tree Number:
D03.383.679.149
Definition
English
:
A pyrazine compound inhibiting
SODIUM
reabsorption through
SODIUM CHANNELS
in renal
EPITHELIAL CELLS
. This inhibition creates a negative potential in the luminal
membranes
of principal
cells
, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of
potassium
and
hydrogen
ions
.
Amiloride
is used in conjunction with
DIURETICS
to spare
POTASSIUM
loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of
Therapeutics
, 9th ed, p705)
Pharmacological Action:
Diuretics
Sodium Channel Blockers
History Note
English
:
86(72); was see under PYRAZINES 1975-85, was Prov 1972-74
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
588
Unique Identifier:
D000584
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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