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ALTERNATIVE COMPLEMENT PATHWAY
Descriptors Found:
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DeCS
Descriptor
English
:
Complement Pathway, Alternative
Descriptor
Spanish
:
Vía Alternativa del Complemento
Descriptor
Portuguese
:
Via Alternativa do Complemento
Synonyms
English
:
Alternative Complement Pathway
Properdin Pathway
Tree Number:
G12.425.255.695
Definition
English
:
Complement activation
initiated by the interaction of microbial
ANTIGENS
with
COMPLEMENT C3B
. When
COMPLEMENT FACTOR B
binds to the membrane-bound C3b,
COMPLEMENT FACTOR D
cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple
COMPLEMENT C3
to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of
COMPLEMENT C5
and the assembly of
COMPLEMENT MEMBRANE ATTACK COMPLEX.
History Note
English
:
91(79); was see under COMPLEMENT ACTIVATION 1979-90
Allowable Qualifiers
English
:
DE
drug effects
ES
ethics
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects
Record Number:
3216
Unique Identifier:
D003170
Occurrence in VHL
:
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